Habib Fallahnejad; Hossein Omidi; Sirous Khorram; Mehran Mesgari; Mohammad Asghari-Jafarabadi; Ali Tarighat-Esfanjani
Volume 20, Issue 10 , 2018, Pages 1-7
Abstract
Background: Natural nano-sized Clinoptilolite (NCLN) as a conventional treatment for Type 2 diabetes mellitus may reduce glucose concentration and improve levels of minerals and lipid profile (LP). Objectives: The aim of this study was to compare the effects of NCLN with Metformin (Met) on fasting blood ...
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Background: Natural nano-sized Clinoptilolite (NCLN) as a conventional treatment for Type 2 diabetes mellitus may reduce glucose concentration and improve levels of minerals and lipid profile (LP). Objectives: The aim of this study was to compare the effects of NCLN with Metformin (Met) on fasting blood glucose (FBG), LP, levelsof the several minerals, and body weight (BW) in rats with high-fat-diet (HFD)/Streptozotocin (STZ)-induced diabetes.Methods: In this experimental study, 33 male Wistar rats were divide into four groups of A) healthy (n = 6), B) diabetic: (1) NCLN (n = 9) 2% of food, (2) diabetic receiving Met (n = 9) 100 mg/kg BW/day and (3) diabetic control (DC) (n = 9). The diabetic subgroups were fed with an HFD for one month and injected with a single dose of intra-peritoneal STZ (35 mg/kg BW). At the end of the 7th week, FBG, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), LP, and serum levels of some minerals were evaluated. Results: There were no significant differences in FBS, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein choles- terol (LDL-c) among the groups, however, high-density lipoprotein cholesterol (HDL-c) level was significantly higher in the DM (32.92 ± 1.14) and NCLN (32.63 ± 0.73) groups in comparison with the DC group (31.64 ± 0.78) (P = 0.01). The mean score of Cu level in theDM group was significantly different from that in the DC group (2.15 ± 0.48 vs. 1.54 ± 0.21; P = 0.03). Moreover, Met significantly increased serum level of Ca as compared to the DC group (86.65 ± 10.03; P = 0.01). Also, treatment with Met favorably prevented severe weight loss until the last week of treatment. Conclusions: Natural nano-sized Clinoptilolite and/or Met did not significantly affect levels of serum glucose, minerals, and lipid profile, but a significant increase in HDL-c was observed as a result of NCLN and Metformin treatment, and Cu and Ca levels increased only in the Metformin group.
Aida Ghaffari; Maryam Rafraf; Roya Navekar; Bita Sepehri; Mohammad Asghari-Jafarabadi; Seyyed-Mostafa Ghavami; Nahid Manaf
Volume 19, Issue 4 , April 2017, , Pages 1-7
Abstract
Background: Elevated levels of homocysteine (Hcy) and fetuin-A are important risk factors for cardiovascular diseases in patients with a nonalcoholic fatty liver disease (NAFLD). There is limited evidence regarding the effects of turmeric on NAFLD.Objectives: This study aimed at investigating the effects ...
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Background: Elevated levels of homocysteine (Hcy) and fetuin-A are important risk factors for cardiovascular diseases in patients with a nonalcoholic fatty liver disease (NAFLD). There is limited evidence regarding the effects of turmeric on NAFLD.Objectives: This study aimed at investigating the effects of turmeric supplementation on serum levels of Hcy and fetuin-A in patients with NAFLD.Methods: In this double-blind, randomized, controlled clinical trial, 46 NAFLD patients (21 males and 25 females; age range, 20 - 60 years) with body mass index ranged 24.9 - 40 kg/m2 were recruited from Sheikh-ol-Raees clinic in Tabriz City, Iran during Nov 2014-May 2015. The participants were allocated into the two groups using the block randomization method. The intervention and control groups received 3g of turmeric (n = 23) and placebo (n = 23), daily for 12 weeks. Fasting blood samples were collected at baseline and at the end of the trial for biochemical analysis.Results: Turmeric supplementation significantly decreased serum levels of Hcy, compared with the placebo group at the end of the study (by 27.83%, P = 0.034). No significant difference was observed between the two groups in serum levels of fetuin-A after the intervention (P > 0.05). Serum levels of glucose, insulin and homeostasis model assessment for insulin resistance were declined significantly in the turmeric group (by 1.22%, 17.69% and 19.48%, P = 0.039, P = 0.013 and P = 0.001, respectively) compared to the placebo.Conclusions: Turmeric consumption had beneficial effects on serum Hcy levels and may be useful in management of this risk factor in NAFLD patients.
